He started his career at "Obolon", followed by "Dynamo" Kyiv, including "Dynamo 2", where the midfielder played most of his matches. Then there were "Hoverla" and "Vorskla".
In the 2019/2020 season, Myakushko played for "Karpaty", and then he moved to the second Spanish division, where he defended the colors of "Alcorcorn". Then there was Poland, the club "Podbeskidze" from Bielsko-Biala. And in the fall of last year, Serhii became a player of "Minaj". The player has a challenge to the ranks of the national team of Ukraine, where he played one friendly match in 2017 against Slovakia.